The ERA-Net “E-Rare” for research programmes on rare diseases has entered the third phase “E-Rare-3” to further help in coordinating the research efforts of European countries in the field of rare diseases and implement the objectives of International Rare Disease Research Consortium (IRDiRC). The aim of the currently open call is to enable scientists in different countries to build an effective collaboration on a common interdisciplinary research project based on complementarities and sharing of expertise, with a clear translational research approach.